Postdoctoral Research Scientist

You will need to download, save, and complete a copy of the application form using Microsoft Word or prepare a copy of your CV that contains all the information requested in the application form. The post-holder will be part of a wider consortium based in both Hinxton, Cambridge (Wellcome Trust Sanger Institute and EMBL-EBI) and Edinburgh (University of Edinburgh, Heriot-Watt University and NHS Lothian, Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine). Background: At EI, the post holder will have access to cutting-edge high-performance computing facilities and expertise. They will join an active community of experimental and computational biologists working on a wide range of cellular genomics and single-cell analyses. They will have the opportunity to contribute to other projects and the overall development and implementation of single-cell genomic approaches at EI. The role: The aims of the project are: Perform analyses of the scRNA-Seq data to reveal cell types, subtypes/states, and transition trajectories within the spatial organisation of the normal gut. Develop tools to analytically combine scRNA-Seq and images from histology sections, as well as spatial transcriptomics. Perform bioinformatic investigations to understand the pathogenesis and progression of Crohn’s Disease. This is a 2-year post fully funded by The Helmsley Charitable Trust. The post holder will contribute to the Gut Cell Atlas – normal and Crohn’s Disease research programme, which aims to combine single-cell transcriptomics data from patient-derived samples (normal and Crohn’s Disease) with advanced image-based 2-D and 3-D gut atlas data. The research programme team also forms part of a growing research network of Helmsley-funded Human Gut Cell Atlas (normal and Crohn’s Disease) research groups worldwide. The main aim of the position is to work in a multi-disciplinary, collaborative environment to make advances in Crohn’s Disease research. The successful candidate will establish good working relationships with the co-applicants (Mark Arends, Shahida Din, Richard Baldock, Albert Burger, David Adams, of Lothian Health Board, University of Edinburgh, Heriot-Watt University and Wellcome Trust Sanger Institute). They will be expected to visit Edinburgh several times each year to collaborate with the Edinburgh team members on integration of data of all types from the project. You will work closely with our experimental collaborators in Edinburgh, but the approaches you will develop will also be extended to other similar data sets. Your methods will directly contribute to the analysis pipelines of the Earlham Institute’s core open workflows and computational tools. The ideal candidate: The successful candidate will have a PhD in bioinformatics, computational biology, or a related subject with experience of working on single-cell transcriptomics and spatial transcriptomics data. They will have a solid understanding of statistics of biology, and it is advantageous if they have experience with long-read sequencing. Additional information: Salary on appointment will be within the range £36,720 - £39,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 24 months. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The closing date for applications will be 6 January 2025.

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