School/Section
Medicine, Medical Sciences & Nutrition Division
Institute of Medical Sciences Staff Category
Research Position Type
Full Time Grade
Grade 6 Salary
£37,999 - £40,247 Ref No
IMS301R Closing Date
06-JAN-2025 The Sutherland lab, based at the University of Aberdeen, studies lung diseases at the interface between immunology and extracellular matrix biology. We are seeking to appoint a highly motivated, creative and experienced research fellow to be part of an exciting collaborative research programme studying IL-13 immune regulation of hyaluronan extracellular matrices during lung injury, repair and chronic pathology. This project will work closely alongside an established collaborative team at the University of Manchester and the University of Virginia and is supported by a Wellcome Discovery Award. Job Description
The ideal candidate will have a PhD background in immunology, biochemistry, computational biology (with some experience in wet-lab research) or related biomedical sciences background. The postdoctoral fellow will be responsible for performing experiments to investigate the interactions between immune cells, lung tissue cells and the extracellular matrix that influence the outcomes of acute versus chronic pathology in the lung. A combination of cutting-edge high-dimensional spatial proteomics and transcriptomics, a range of immunological and biochemical assays, in vivo mouse models and 3D lung slice cultures will be used throughout the project. The fellow will be responsible for planning, performing and analysing experiments, collaborating with other lab members and external project partners, and contributing to lab upkeep. Experience with matrix biology and computational analysis is an asset. This collaborative project has a particular focus on the extracellular matrix component hyaluronan, an enormous polysaccharide that dictates tissue elasticity, hydration and directs immune cell behaviour. During lung inflammation, hyaluronan content increases dramatically and can be driven by the type 2 cytokine IL-13. Hyaluronan also becomes modified by hyaluronan-binding proteins to form diverse HA matrix structures which are essential for effective tissue repair but are also a key component of the pathogenic matrix that forms in asthma, influenza, and COVID-19. The appointed research fellow will specifically work on studying hyaluronan matrices in chronic lung pathology and work toward spatially mapping the hyaluronan matrices in the lung, defining how immune responses instruct matrix formation, and manipulating hyaluronan matrices to address their impact on disease outcome for therapeutic benefit. Salary will be at the appropriate point on the Grade 6 scale, £37,999 - £40,247 per annum, and negotiable with placement according to qualifications and experience. To apply online for this position visit
www.abdn.ac.uk/jobs . Job Reference Number: IMS301R The closing date for the receipt of applications is 06 January 2025. Please Note
If you are unable to complete an application online, please contact the Recruitment Team (HRRecruitment@abdn.ac.uk) to make alternative arrangements for submitting your application within plenty of time before the advertised post closes.
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Medicine, Medical Sciences & Nutrition Division
Institute of Medical Sciences Staff Category
Research Position Type
Full Time Grade
Grade 6 Salary
£37,999 - £40,247 Ref No
IMS301R Closing Date
06-JAN-2025 The Sutherland lab, based at the University of Aberdeen, studies lung diseases at the interface between immunology and extracellular matrix biology. We are seeking to appoint a highly motivated, creative and experienced research fellow to be part of an exciting collaborative research programme studying IL-13 immune regulation of hyaluronan extracellular matrices during lung injury, repair and chronic pathology. This project will work closely alongside an established collaborative team at the University of Manchester and the University of Virginia and is supported by a Wellcome Discovery Award. Job Description
The ideal candidate will have a PhD background in immunology, biochemistry, computational biology (with some experience in wet-lab research) or related biomedical sciences background. The postdoctoral fellow will be responsible for performing experiments to investigate the interactions between immune cells, lung tissue cells and the extracellular matrix that influence the outcomes of acute versus chronic pathology in the lung. A combination of cutting-edge high-dimensional spatial proteomics and transcriptomics, a range of immunological and biochemical assays, in vivo mouse models and 3D lung slice cultures will be used throughout the project. The fellow will be responsible for planning, performing and analysing experiments, collaborating with other lab members and external project partners, and contributing to lab upkeep. Experience with matrix biology and computational analysis is an asset. This collaborative project has a particular focus on the extracellular matrix component hyaluronan, an enormous polysaccharide that dictates tissue elasticity, hydration and directs immune cell behaviour. During lung inflammation, hyaluronan content increases dramatically and can be driven by the type 2 cytokine IL-13. Hyaluronan also becomes modified by hyaluronan-binding proteins to form diverse HA matrix structures which are essential for effective tissue repair but are also a key component of the pathogenic matrix that forms in asthma, influenza, and COVID-19. The appointed research fellow will specifically work on studying hyaluronan matrices in chronic lung pathology and work toward spatially mapping the hyaluronan matrices in the lung, defining how immune responses instruct matrix formation, and manipulating hyaluronan matrices to address their impact on disease outcome for therapeutic benefit. Salary will be at the appropriate point on the Grade 6 scale, £37,999 - £40,247 per annum, and negotiable with placement according to qualifications and experience. To apply online for this position visit
www.abdn.ac.uk/jobs . Job Reference Number: IMS301R The closing date for the receipt of applications is 06 January 2025. Please Note
If you are unable to complete an application online, please contact the Recruitment Team (HRRecruitment@abdn.ac.uk) to make alternative arrangements for submitting your application within plenty of time before the advertised post closes.
#J-18808-Ljbffr
