Computational Biologist/Bioinformatician
Prof Payam Gammage
Mitochondrial genetic variation in tumour biology
Salary:
from £36,851 to £45,357 subject to experience, plus relocation allowance and visa costs if required. Contract term:
Fixed up to December 2027 (external funding end) About us The CRUK Scotland Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned
in vivo
modelling of tumour growth and metastasis. Project outline The Mitochondrial Oncogenetics lab studies the role of mitochondrial DNA (mtDNA) mutation and metabolic dysfunction in cancer (Kim
et al ., 2022). Our recent discoveries (Gorelick
et al ., 2021; Mahmood
et al ., 2024) have led to the understanding that mtDNA mutations are highly prevalent in cancer, and can sensitise cancers to immune-oncology treatments. Approaches to treating cancer such as immune checkpoint inhibitors, are highly effective in some patient populations and cancer types, while others remain effectively untreatable. We aim to develop a mature understanding of the impact of mtDNA mutation and metabolic stress in tumours to enable new approaches to treating cancer. A vacancy for a Computational Biologist/Bioinformatician is available for an ambitious scientist to work alongside wet lab scientists within the Mitochondrial Oncogenetics group, leading on the interrogation and integration of multi-modal data arising from both preclinical models and patients. The postholder will work with a range of multi-omic platforms, including bulk, single cell and spatial transcriptomic, proteomic and metabolomic analyses including samples from state-of-the-art mouse models of mitochondrial mutant cancer. The post will involve working in a GPU-enabled, High Performance Computing environment as part of a highly interdisciplinary team that brings together metabolism, cancer biology, biochemistry, genome engineering and in vivo approaches. Minimum Requirements Applicants will have a PhD in bioinformatics, or related discipline, significant experience working with bulk and single cell RNA and/or cancer genomics datasets, and the use of R and BioConductor for data analysis. For informal enquiries, please email payam.gammage@glasgow.ac.uk Equality, Diversity and Inclusion Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters. Employee Benefits Competitive salary 40.5 days annual leave including bank holidays (pro-rata) Defined Contribution pension scheme Life Insurance scheme Employee Assistance Programme Season ticket loan Additional maternity pay at 6 month’s full pay (subject to service) Shared parental leave Cycle to work scheme that could save you 26-40% on a bike and accessories. Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more. On-site secure parking All applications must be made via our website at:
https://www.crukscotlandinstitute.ac.uk/careers/computing.html Closing Date:
7th February 2025 Job Types: Full-time, Fixed term contract Contract length: 36 months Pay: £36,851.00-£45,357.00 per year Benefits: Canteen Casual dress Company pension Cycle to work scheme Enhanced maternity leave Health & wellbeing programme Life insurance On-site parking Schedule: Day shift Monday to Friday Work Location:
In person
#J-18808-Ljbffr
from £36,851 to £45,357 subject to experience, plus relocation allowance and visa costs if required. Contract term:
Fixed up to December 2027 (external funding end) About us The CRUK Scotland Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned
in vivo
modelling of tumour growth and metastasis. Project outline The Mitochondrial Oncogenetics lab studies the role of mitochondrial DNA (mtDNA) mutation and metabolic dysfunction in cancer (Kim
et al ., 2022). Our recent discoveries (Gorelick
et al ., 2021; Mahmood
et al ., 2024) have led to the understanding that mtDNA mutations are highly prevalent in cancer, and can sensitise cancers to immune-oncology treatments. Approaches to treating cancer such as immune checkpoint inhibitors, are highly effective in some patient populations and cancer types, while others remain effectively untreatable. We aim to develop a mature understanding of the impact of mtDNA mutation and metabolic stress in tumours to enable new approaches to treating cancer. A vacancy for a Computational Biologist/Bioinformatician is available for an ambitious scientist to work alongside wet lab scientists within the Mitochondrial Oncogenetics group, leading on the interrogation and integration of multi-modal data arising from both preclinical models and patients. The postholder will work with a range of multi-omic platforms, including bulk, single cell and spatial transcriptomic, proteomic and metabolomic analyses including samples from state-of-the-art mouse models of mitochondrial mutant cancer. The post will involve working in a GPU-enabled, High Performance Computing environment as part of a highly interdisciplinary team that brings together metabolism, cancer biology, biochemistry, genome engineering and in vivo approaches. Minimum Requirements Applicants will have a PhD in bioinformatics, or related discipline, significant experience working with bulk and single cell RNA and/or cancer genomics datasets, and the use of R and BioConductor for data analysis. For informal enquiries, please email payam.gammage@glasgow.ac.uk Equality, Diversity and Inclusion Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters. Employee Benefits Competitive salary 40.5 days annual leave including bank holidays (pro-rata) Defined Contribution pension scheme Life Insurance scheme Employee Assistance Programme Season ticket loan Additional maternity pay at 6 month’s full pay (subject to service) Shared parental leave Cycle to work scheme that could save you 26-40% on a bike and accessories. Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more. On-site secure parking All applications must be made via our website at:
https://www.crukscotlandinstitute.ac.uk/careers/computing.html Closing Date:
7th February 2025 Job Types: Full-time, Fixed term contract Contract length: 36 months Pay: £36,851.00-£45,357.00 per year Benefits: Canteen Casual dress Company pension Cycle to work scheme Enhanced maternity leave Health & wellbeing programme Life insurance On-site parking Schedule: Day shift Monday to Friday Work Location:
In person
#J-18808-Ljbffr
