Senior Clinical Research Fellow in Hepatology (ST4+)

Detailed job description and main responsibilities This research project will be centred on investigating immunopathology and susceptibility to infection in patients with acute decompensated cirrhosis and acute-on-chronic liver failure (ACLF). It may include evaluating immune checkpoints on innate and adaptive immune cells, their role on immune cell function in the circulation and mechanisms of microbial translocation in contributing to septic and portal hypertensive complications in this cohort of patients. Depending on timelines and recruitment, the candidate may also be involved in a scientific sub-study of the PROMISE trial, a national multicentre study evaluating faecal microbiome transplantation vs. placebo in cirrhosis. In particular, the candidate would undertake laboratory work to determine the changes to monocyte phenotype and function with this intervention. Their laboratory work may involve collaboration and work at other London centres including King's College London and Imperial College London as part of a wider collaborative research group. The candidate will be involved in patient screening, recruitment and biological sampling. They will be taught basic lab-based immunological techniques to generate novel data with no prior lab experience necessary. They will be supported in the lab by clinician scientist Dr Arjuna Singanayagam with support of the other members of the lab group. The aim would be to generate preliminary data sufficient to apply for external grant funding. If the candidate has specific research interests within the area of complications of cirrhosis or immune dysfunction in liver disease, the project can be negotiated. The successful candidate will be expected to register for an MD or PhD higher research degree with St. George's University of London (SGUL) with supervision from Dr Singanayagam and Professor Forton. Person specification Qualifications and Training Essential criteria MBBS or equivalent MRCP Full GMC Registration Experience Essential criteria Experience of audit and research methodology Desirable criteria ST3+ gastro/hepatology training post or equivalent Independent upper GI endoscopist Experience on GI bleed rota Skills Essential criteria Computer skills including the ability to manage databases and image processing systems, which generate reliable research and clinical outcome data sets Understand principles of audit Understand principles and able to understand research results Knowledge Essential criteria Good medical knowledge and clinical skills Clear, legible documentation Desirable criteria Some evidence of involvement in research or presentations at meetings/publications Other Essential criteria Commitment to learning Potential to cope with stressful situations and undertake responsibility Excellent communication and interpersonal skills Team worker and able to work independently using initiative We expect all our staff to share the values that are important to the trust - being excellent, kind, responsible and respectful - and behave in a way that reflects these. More information on the vision and values of St. George's University Hospitals NHS Foundation Trust is attached below. Please note that this vacancy may close before the advertised closing date if sufficient applicants are received. Please check your email regularly as all candidates shortlisted for interview will be contacted and informed by email. If you are appointed to the post, as part of your pre-employment check we will be required to verify your identity. The document/s you present for this purpose will be checked for their authenticity by scanning all known security features. These features will include: The machine readable zone An ultra violet image An infra red image As part of your pre-employment checks, we will also be required to obtain satisfactory, written references. Please ensure that the referee details which you provide on your application form are correct. We require at least one written reference from your current or most recent line manager. We are only able to accept references from a professional work email address. Disability Advice Line:

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Confidential Disability Advice Line at: Telephone: 02082963786 Text: 07501066267 Email: esth.dal@nhs.net. Our confidential answering service is available after 5pm. Employer certification / accreditation badges Applicant requirements You must have appropriate UK professional registration. This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service. Documents to download Job Description (PDF, 280.6KB) Referee Contact details form (PDF, 200.6KB)

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