Job Title : Postdoctoral Fellow
Details of the role : 4-year fixed term contract, full time. Working pattern: Monday - Friday.
Salary : From £43,210 dependent on skills and experience
Application closing date : 28/02/25
About us
The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture.
About the role
The Protein Biogenesis at the Francis Crick institute is looking for a postdoc to help us understand the molecular principles underlying protein folding in vivo. Our team is focused on determining how the cellular environment shapes pathways of protein folding.
Project directions include studies of protein folding and assembly in bacteria and human cells, the coordination between protein synthesis and molecular chaperones, and principles of nascent protein quality control at the ribosome.
What you will be doing
As a
Postdoctoral Fellow
at the Crick, a number of projects are available, depending on the interest and expertise of the applicant. Open questions include: What conformations do nascent and stress-denatured proteins adopt in vivo? What is the function of molecular chaperones during cotranslational folding? How are defective nascent polypeptides recognised and routed to quality control machinery? What are the molecular principles underlying substrate recognition by chaperones? Methods used in the group include biochemical reconstitution, hydrogen/deuterium exchange- and crosslinking-mass spectrometry, cryo-electron microscopy, proteomics and fluorescence microscopy. About you You will bring PhD awarded or in the final stages of PhD submission Track record of writing papers as evidenced by publications, preprints or submitted manuscripts Expertise in protein biochemistry Experience in mechanistic studies of protein folding, molecular chaperones, or ribosomes. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visa s: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Schem e: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure with performance-linked progression.
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Postdoctoral Fellow
at the Crick, a number of projects are available, depending on the interest and expertise of the applicant. Open questions include: What conformations do nascent and stress-denatured proteins adopt in vivo? What is the function of molecular chaperones during cotranslational folding? How are defective nascent polypeptides recognised and routed to quality control machinery? What are the molecular principles underlying substrate recognition by chaperones? Methods used in the group include biochemical reconstitution, hydrogen/deuterium exchange- and crosslinking-mass spectrometry, cryo-electron microscopy, proteomics and fluorescence microscopy. About you You will bring PhD awarded or in the final stages of PhD submission Track record of writing papers as evidenced by publications, preprints or submitted manuscripts Expertise in protein biochemistry Experience in mechanistic studies of protein folding, molecular chaperones, or ribosomes. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visa s: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Schem e: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure with performance-linked progression.
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