Principal Scientist (Biochemistry/Enzymology)
Principal Scientist (Biochemistry/Enzymology)
Apply locations CRT Cambridge (Babraham) Cancer Research UK Scotland Institute Time type : Full time Posted on : Posted Yesterday Time left to apply : End Date: February 10, 2025 (11 days left to apply) Job requisition id : R030366 Starting salary : From £50,400-£57,400 per annum depending on experience plus
benefits Reports to : Group Leader Mechanistic Pharmacology Department : Research and Innovation Contract : Permanent Hours : Full time 35 hours per week (flexible working requests considered if they meet business needs) Location : Babraham Research Campus, Cambridge or Scotland Institute, Glasgow Closing date : 9 February 2025 23:55. This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. Visa sponsorship : Cancer Research UK
can
consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application. About CRUK Drug Discovery As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world-class biology, cutting-edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. What will I be doing? This role is focused on designing and developing physiologically relevant biochemical assays to characterise cancer targets in detail at the molecular level, enable high-throughput screening, profile the structure-activity and structure-kinetic relationships of small molecules, and characterise their mechanism of action to inform dose prediction and clinical efficacy. The successful candidate will drive innovative ways of working through keeping abreast of cutting-edge biochemistry and enzymology. They will form an integral part of the Cancer Research Horizon Drug Discovery team working alongside our industry and academic partners to progress novel cancer targets towards patient benefit. What skills will I need? A BSc, MSc or PhD in biochemistry or in vitro pharmacology; relevant experience may be substituted for education Significant experience in a drug discovery environment of dissecting enzyme and small molecule inhibitor mechanisms Detailed understanding of steady-state and pre-steady-state enzymology. Experience in Modelling and Simulation will be an advantage. Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems Significant experience of assay development for a range of target classes Demonstrated scientific leadership skills with ability to give strategic direction Credible external reputation, as evidenced through publication, presentation at key conferences, and a strong personal network What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. How do I apply? We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.
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Apply locations CRT Cambridge (Babraham) Cancer Research UK Scotland Institute Time type : Full time Posted on : Posted Yesterday Time left to apply : End Date: February 10, 2025 (11 days left to apply) Job requisition id : R030366 Starting salary : From £50,400-£57,400 per annum depending on experience plus
benefits Reports to : Group Leader Mechanistic Pharmacology Department : Research and Innovation Contract : Permanent Hours : Full time 35 hours per week (flexible working requests considered if they meet business needs) Location : Babraham Research Campus, Cambridge or Scotland Institute, Glasgow Closing date : 9 February 2025 23:55. This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. Visa sponsorship : Cancer Research UK
can
consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application. About CRUK Drug Discovery As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world-class biology, cutting-edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. What will I be doing? This role is focused on designing and developing physiologically relevant biochemical assays to characterise cancer targets in detail at the molecular level, enable high-throughput screening, profile the structure-activity and structure-kinetic relationships of small molecules, and characterise their mechanism of action to inform dose prediction and clinical efficacy. The successful candidate will drive innovative ways of working through keeping abreast of cutting-edge biochemistry and enzymology. They will form an integral part of the Cancer Research Horizon Drug Discovery team working alongside our industry and academic partners to progress novel cancer targets towards patient benefit. What skills will I need? A BSc, MSc or PhD in biochemistry or in vitro pharmacology; relevant experience may be substituted for education Significant experience in a drug discovery environment of dissecting enzyme and small molecule inhibitor mechanisms Detailed understanding of steady-state and pre-steady-state enzymology. Experience in Modelling and Simulation will be an advantage. Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems Significant experience of assay development for a range of target classes Demonstrated scientific leadership skills with ability to give strategic direction Credible external reputation, as evidenced through publication, presentation at key conferences, and a strong personal network What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. How do I apply? We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.
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