Antibody Engineering Manager

Reporting to the Operations Manager, the role of Antibody Engineering Manager will be responsible for all aspects of protein engineering, particularly monoclonal antibody drugs. This will include multi-specific antibody design, affinity maturation, protein-protein docking, developability analysis, humanization and antigen design. The Antibody Engineering Manager will manage a team of scientists while acting as a liaison with other business units. Primary Position Responsibilities/Tasks: Responsibility for planning, implementation and management of projects (including liaising with clients on a weekly basis). Share and discuss data with management to ensure production demands are met within agreed timelines. Responsible for the line management and development of other scientific staff within Fusion (support and supervision, training, staff appraisals etc). Ensuring reports/results shared with clients are of a high standard. Responsible for addressing all aspects of Antibody Engineering within the company including Antibody Humanization, Antibody Developability, Multispecific Antibody Reformatting and Antibody Affinity Maturation (RAMP). Work cohesively with the R&D team to develop new innovative Antibody Engineering technology. Responsible for introducing state of the art technology into the antibody engineering workflow including machine learning for drug discovery and optimization. Responsible for overseeing antigen design and working cohesively with the Discovery Team to ensure client expectations are met. Responsible for working cohesively with the Production team to ensure the smooth transition of vital information between teams. Keep abreast of advancements within their area of expertise. Ensure proprietary and external software in the Antibody Engineering department is up to date and functioning optimally. Prepare and present oral and written reports on research activities to internal and external audiences. To act of the main point of contact for Fusion clients. Provide technical consultancy to the business development team and lead technical calls with prospective and current clients. Be proactive with their own CPD (continued personal development). Ensure that all duties are performed in accordance with organisational standards, policies and procedures. Perform other duties as assigned. Job Specification PhD in Bioinformatics, Computational Chemistry/Biology or related field, or MSc with 1+ years of industry experience. Key skills of the post holder include project management and excellent communication Experience with MS office applications. Industrial experience in computational biology, immuno-informatics, protein engineering, or structural biology. Familiar with machine learning methods used in protein/antibody engineering. Software engineering skills, especially with the Python programming language. Familiar with NGS repertoire analysis. Have the ability to mentor more junior members of the team and also be able to share your specialist knowledge with those you collaborate with. Familiarity with working in an ISO 9001:2015 environment.

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