Job description
Site Name:
UK - Hertfordshire - Stevenage Posted Date:
Jan 15 2025
The Discovery Chemistry group works with partners across the organisation leveraging AI/ML predictive models to design and synthesise drug candidates across a range of modalities including small molecules, antibody drug conjugates and targeted protein degraders. The team brings together medicinal chemistry, synthetic organic chemistry, bioconjugation and parallel chemistry experience to deliver first-in-class and best-in-class medicines, uniting science, technology and talent to get ahead of disease together. We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. In this role you will Carry out experimental work within the Discovery Chemistry group. This will involve designing and executing synthetic plans to deliver small molecules and modalities including targeted protein degraders and antibody drug conjugates for biological evaluation. In addition to the laboratory component of this role, this will also involve analysing data, and designing compounds to test medicinal chemistry hypotheses. Develop and implement strategies for efficient and high-quality synthesis, purification, and characterisation of molecules. Leverage AI/ML predictive models to design drug molecules across multiple modalities including antibody-drug-conjugates, small molecules, and targeted protein degraders. Stay up to date with the latest advancements in chemistry, medicinal chemistry and technologies aligned to the Discovery Chemistry remit. Be committed to personal professional development. Basic Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: Very good degree or equivalent in chemistry and a PhD/DPhil in medicinal chemistry/synthetic chemistry/chemical biology/targeted protein degraders/ADCs. Significant and varied experiences working with modalities such as targeted protein degraders and/or antibody drug conjugates in a professional research environment(s). A strong understanding of medicinal chemistry principles and their use within a drug discovery setting. A good understanding of practical organic chemistry and current synthetic methodology is an essential requirement as shown by an extensive track record of high synthetic productivity, route design and problem solving. Ability to understand, interpret and communicate complex scientific data. Excellent written and oral communication skills enabling efficient presentation of scientific findings to both technical and non-technical audiences. Track record of peer reviewed publications. A record of presenting at scientific meetings is also expected. Preferred Qualifications & Skills: Please note the following skills are not necessary, just preferred, if you do not have them, please still apply: Experience using AI/ML predictive models and MPO to accelerate drug discovery. Experience of synthesising and handling low OEL compounds and safety protocols required for working with such compounds. Attention to detail and ability to work in a fast-paced and dynamic environment. Excellent problem-solving analytical, and critical thinking skills. Closing Date for Applications – 5th Feb 2025 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
#J-18808-Ljbffr
UK - Hertfordshire - Stevenage Posted Date:
Jan 15 2025
The Discovery Chemistry group works with partners across the organisation leveraging AI/ML predictive models to design and synthesise drug candidates across a range of modalities including small molecules, antibody drug conjugates and targeted protein degraders. The team brings together medicinal chemistry, synthetic organic chemistry, bioconjugation and parallel chemistry experience to deliver first-in-class and best-in-class medicines, uniting science, technology and talent to get ahead of disease together. We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. In this role you will Carry out experimental work within the Discovery Chemistry group. This will involve designing and executing synthetic plans to deliver small molecules and modalities including targeted protein degraders and antibody drug conjugates for biological evaluation. In addition to the laboratory component of this role, this will also involve analysing data, and designing compounds to test medicinal chemistry hypotheses. Develop and implement strategies for efficient and high-quality synthesis, purification, and characterisation of molecules. Leverage AI/ML predictive models to design drug molecules across multiple modalities including antibody-drug-conjugates, small molecules, and targeted protein degraders. Stay up to date with the latest advancements in chemistry, medicinal chemistry and technologies aligned to the Discovery Chemistry remit. Be committed to personal professional development. Basic Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: Very good degree or equivalent in chemistry and a PhD/DPhil in medicinal chemistry/synthetic chemistry/chemical biology/targeted protein degraders/ADCs. Significant and varied experiences working with modalities such as targeted protein degraders and/or antibody drug conjugates in a professional research environment(s). A strong understanding of medicinal chemistry principles and their use within a drug discovery setting. A good understanding of practical organic chemistry and current synthetic methodology is an essential requirement as shown by an extensive track record of high synthetic productivity, route design and problem solving. Ability to understand, interpret and communicate complex scientific data. Excellent written and oral communication skills enabling efficient presentation of scientific findings to both technical and non-technical audiences. Track record of peer reviewed publications. A record of presenting at scientific meetings is also expected. Preferred Qualifications & Skills: Please note the following skills are not necessary, just preferred, if you do not have them, please still apply: Experience using AI/ML predictive models and MPO to accelerate drug discovery. Experience of synthesising and handling low OEL compounds and safety protocols required for working with such compounds. Attention to detail and ability to work in a fast-paced and dynamic environment. Excellent problem-solving analytical, and critical thinking skills. Closing Date for Applications – 5th Feb 2025 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
#J-18808-Ljbffr
