We are seeking a scientist with a proven track record of cellular and molecular proteomics, analytical chemistry and/or biochemistry to play a key supporting role in the MS-based proteomics group in precision medicine and computational biology. The scientist will contribute to the development of proteomic workflows using robotics and automated liquid handlers with the outcome to accelerate and alleviate the manual-intensive aspects of sample prep, increasing throughput and depth. The candidate will apply new and established workflows to biological systems and various sample types (tissues, biofluids, and cells) for biomarker discovery and mechanism of action studies.
The candidate will work with cross-functional teams and across different therapeutic areas and academic collaborators on these projects.
Key Responsibilities
Contribute to innovative therapeutic platforms and apply cutting-edge proteomic technologies for disease profiling and biomarker discovery. Generate proteomic datasets for disease profiling and mechanism of action studies. Assist in instrument troubleshooting, maintenance, and repairs. Minimum Qualifications
MS and 3+ years or equivalent, BS with 5+ years relevant lab experience in biochemistry, proteomics, analytical chemistry, or related field in academic, pharma or biotech industry, or PhD with 0-1 years postgraduate experience. Hands-on experience with proteomics, minimum 1 year of hands-on lab experience. Hands-on experience with executing, optimizing, and developing proteomic sample preparations (e.g., extractions, SPE, digestion, peptide labeling protocols) from cells, tissues, or biofluids for mass spec analysis. Cell culture experience is a plus. Preferred Experience
Sample preparation of limited tissue samples with ultrasensitive proteomics. Hands-on targeted proteomic approaches. Hands-on co-immunoprecipitations, affinity-based protein profiling, chemoproteomics. Analysis of proteomic data sets, coding experience in R or Python.
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Contribute to innovative therapeutic platforms and apply cutting-edge proteomic technologies for disease profiling and biomarker discovery. Generate proteomic datasets for disease profiling and mechanism of action studies. Assist in instrument troubleshooting, maintenance, and repairs. Minimum Qualifications
MS and 3+ years or equivalent, BS with 5+ years relevant lab experience in biochemistry, proteomics, analytical chemistry, or related field in academic, pharma or biotech industry, or PhD with 0-1 years postgraduate experience. Hands-on experience with proteomics, minimum 1 year of hands-on lab experience. Hands-on experience with executing, optimizing, and developing proteomic sample preparations (e.g., extractions, SPE, digestion, peptide labeling protocols) from cells, tissues, or biofluids for mass spec analysis. Cell culture experience is a plus. Preferred Experience
Sample preparation of limited tissue samples with ultrasensitive proteomics. Hands-on targeted proteomic approaches. Hands-on co-immunoprecipitations, affinity-based protein profiling, chemoproteomics. Analysis of proteomic data sets, coding experience in R or Python.
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