Salary: £36,720 to £44,000 per annum depending on qualifications and experience
Join an ERC funded research project investigating the inheritance and evolution of human associated microbes. The project will be conducted in a multidisciplinary team at the Quadram Institute and Earlham Institute, and combines newly established patient cohorts, concomitantly developed wetlab and bioinformatics protocols that enable a unique perspective into microbiomes.
The role
How do gut bacteria colonize their human hosts and families? How do they then persist for decades in the same host? And how do they evolve and adapt to their unique human host? How do we investigate bacteria with specialized metabolism in microbiomes? The aim for this post is to dissect the microbial genetics enabling human long-term colonization on a novel family centric cohort established in the UK. High-resolution metagenomics will be used to track microbes – eukaryotic and prokaryotic – across individuals and in families, and determine genes under selection. This will include closely working with metagenomic bioinformatics (assembly, genome binning, gene predictions) and combining this with population genetics and/or network inference algorithms. Thus, exploring microbiomes at unprecedented resolution can resolve eco-evolutionary processes determining resilience and functional plasticity of natural microbiomes. The environment
The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The group has a joint appointment between the Quadram Institute and Earlham Institute to bridge data and life science, developing software such as LotuS2 and MATAFILER and pushing the limits of high-resolution metagenomics. The Norwich Research Park (NRP) UK hosts four BBSRC Institute, more than 15 companies, 3,000 researchers and clinicians, and 17,000 students. The Quadram Institute is an interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. The ideal candidate
The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics, computer science or a related discipline with a background and/or interest in at least one of the following subjects: Microbiomes and biodiversity Metagenomics and patient cohorts Ecology and evolution The ideal candidate will have experience in conducting scientific experiments independently, writing papers, presenting work and grant writing. Basic statistics and programming skills (either R, python, Perl, C++, or equivalent) is essential. Specialized skills will be taught and developed through mentorship and collaborations. Additional information This is a full-time post for a contract of 24 months. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The closing date for applications will be 27 January 2025. Interviews will likely be held on 7 February 2025.
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How do gut bacteria colonize their human hosts and families? How do they then persist for decades in the same host? And how do they evolve and adapt to their unique human host? How do we investigate bacteria with specialized metabolism in microbiomes? The aim for this post is to dissect the microbial genetics enabling human long-term colonization on a novel family centric cohort established in the UK. High-resolution metagenomics will be used to track microbes – eukaryotic and prokaryotic – across individuals and in families, and determine genes under selection. This will include closely working with metagenomic bioinformatics (assembly, genome binning, gene predictions) and combining this with population genetics and/or network inference algorithms. Thus, exploring microbiomes at unprecedented resolution can resolve eco-evolutionary processes determining resilience and functional plasticity of natural microbiomes. The environment
The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The group has a joint appointment between the Quadram Institute and Earlham Institute to bridge data and life science, developing software such as LotuS2 and MATAFILER and pushing the limits of high-resolution metagenomics. The Norwich Research Park (NRP) UK hosts four BBSRC Institute, more than 15 companies, 3,000 researchers and clinicians, and 17,000 students. The Quadram Institute is an interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. The ideal candidate
The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics, computer science or a related discipline with a background and/or interest in at least one of the following subjects: Microbiomes and biodiversity Metagenomics and patient cohorts Ecology and evolution The ideal candidate will have experience in conducting scientific experiments independently, writing papers, presenting work and grant writing. Basic statistics and programming skills (either R, python, Perl, C++, or equivalent) is essential. Specialized skills will be taught and developed through mentorship and collaborations. Additional information This is a full-time post for a contract of 24 months. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The closing date for applications will be 27 January 2025. Interviews will likely be held on 7 February 2025.
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