Senior Director, Diagnostic & HBS Science, Precision Medicine and Biosamples

Job Title: Senior Director, Diagnostic & HBS Science, Precision Medicine and Biosamples Location: Cambridge Salary: competitive Introduction to role: Precision Medicine & Biosamples within AstraZeneca focuses on matching medicines to those patients who will benefit from them most and delivers companion or complementary diagnostic assays that align with the drug development process and enable personalised healthcare approaches within our clinical portfolio. Accountabilities: We are looking for a highly collaborative Senior Director, Diagnostic and Human Biological Samples (HBS) Science, who will be accountable for leading innovative diagnostic science to fulfil precision medicine approaches. You’ll achieve this by overseeing the development of innovative molecular, tissue and protein based diagnostic tests across our portfolio of projects as they prepare for Phase 3 Investment Decision (Ph3ID) with line of sight to use in clinical trials, regulatory submissions and in market testing. This will include leading internal routine laboratory operations and capability growth via our Research and Development (R&D) and College of American Pathologists (CAP)-Clinical Laboratory Improvement Amendments (CLIA) accredited laboratories and strategic partnering to deliver diagnostic tests and tools. The successful candidate will work collaboratively with colleagues within the Precision Medicine and Biosamples function and teams throughout AstraZeneca to deliver expertise to relevant drug product teams and the AZ clinical portfolio. This role will also include collaboration with external diagnostic partners and testing laboratories. As a senior member of the Precision Medicine and Biosamples team you may have responsibility for line and/or project matrix management of staff members, ensuring that all activities are delivered demonstrating behaviours and values aligned to the AstraZeneca code of conduct and supporting policies, standards and procedures including compliant management of budget, safety, health and environment. Essential Skills/Experience: Masters/PhD or equivalent experience in a relevant area Experience of leading a CAP/CLIA or equivalent testing laboratory Experience of developing diagnostic assays in a regulated environment e.g. under In Vitro Diagnostics development standards or within a CAP/CLIA laboratory Expertise with one, or more, of the following technologies IHC, ISH, PCR, NGS, ELISA, digital pathology, emerging diagnostic technologies Understanding of diagnostic development and clinical testing standards and regulations such as Good Clinical Practice, CAP/CLIA, relevant FDA and EMA guidelines Operational experience of setting up clinical diagnostic testing Ability to lead projects and teams in a matrix environment Ability to communicate clearly and influence stakeholders while keeping balanced and objective views Demonstration of a broad lab-based science and technical background Proven leadership ability and portfolio management, global team working and line management experience Desirable Skills/Experience: Experience of Precision Medicine approaches and diagnostic development in Oncology Experience interacting with In Vitro Diagnostics regulatory authorities and commercialisation Experience in drug clinical development and clinical trial design and conduct Proven track record of working with third parties, both commercial and academic Why AstraZeneca? Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It's our big vision that unites and inspires us. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we are aiming to deliver 6 new molecular entities by 2025. A place built on courage, curiosity and collaboration. We make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Pioneers of collaborative research we have built an unrivalled scientific community both internally and externally. Fusing academia and industry, we have united some of the world's foremost medical centres. Working seamlessly and inclusively, together we expedite research in some of the hardest-to-treat cancers. Have the opportunity to build a rewarding and meaningful career as part of the team committed to improving the lives of millions with cancer. So, what’s next? Complete your application before the below closing date. We welcome your application no later than 31 January 2025. Are you ready to make a difference? Apply today and join us in our mission to improve global public health!

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