Job Title
Senior Laboratory Research Scientist Reporting to:
Head of Proteomics STP Contract Term:
This is a full-time permanent position on Crick terms and conditions of employment. Job Overview
The Francis Crick Institute's mission is to understand more about how living things work to help improve treatment, diagnosis, and prevention of human disease, and generate economic opportunities for the UK. Our institute has over 2,000 research staff and students who use their knowledge and expertise to work across disciplines and explore biology at all levels, from molecules through cells to entire organisms. To ensure our scientists can be productive at the highest level, we use a shared access approach to deliver high-end technology and expertise via a suite of core facilities known as Science Technology Platforms (STPs). The Crick STPs provide access to cutting-edge instrumentation and expertise across the range of applications necessary for modern biomedical research, including proteomics. About the Role
We are seeking a talented, experienced, and motivated Senior Laboratory Research Scientist in the Proteomics Scientific Technology Platform (STP) at the Francis Crick Institute. The post holder will help us provide a world-class platform to contribute towards key research in collaboration with the wider Crick scientific community. This is a lab-based position, responsible for driving forward qualitative and quantitative proteomic and clinical proteomic projects, from experimental design through sample preparation to data analysis. Key Responsibilities
Planning of experiments, decision-making about which pipeline to take, and independently executing experiments for projects. Performing both standard and bespoke proteomics experiments starting with sample preparation from a variety of biological sources using common biochemical methodologies for cell lysis, SDS-PAGE, in-gel, in-solution, TCA and acetone precipitation digest protocols, TMT labeling, high pH chromatographic fractionation and label-free quantification. LC-MS/MS nanoUHPLC data acquisition, evaluation, and processing of raw data. Requirements
The post holder should embody and demonstrate our core Crick values:
bold, open, collegial , in addition to the following: A PhD or equivalent experience gained through working in a mass spectrometry laboratory, including basic and advanced proteomic sample handling and processing protocols, and familiarity with instrument maintenance requirements. Detailed understanding of proteomics-related bioinformatics and associated software packages such as PEAKS, Mascot, Scaffold, MaxQuant, Spectronaut, DIA-NN, and Skyline. Experience with developing, optimizing, and applying next-generation proteomics and mass spectrometry methods such as DIA, DDA, label-free profiling, TMT, PRM, etc. Salary and Benefits
The salary for this role is estimated to be around £60,000 - £80,000 per annum, depending on experience. In addition to a competitive salary, we offer a comprehensive benefits package, including pension scheme, annual leave, and training opportunities. How to Apply
If you are interested in applying for this role, please submit your application via our website. All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
Senior Laboratory Research Scientist Reporting to:
Head of Proteomics STP Contract Term:
This is a full-time permanent position on Crick terms and conditions of employment. Job Overview
The Francis Crick Institute's mission is to understand more about how living things work to help improve treatment, diagnosis, and prevention of human disease, and generate economic opportunities for the UK. Our institute has over 2,000 research staff and students who use their knowledge and expertise to work across disciplines and explore biology at all levels, from molecules through cells to entire organisms. To ensure our scientists can be productive at the highest level, we use a shared access approach to deliver high-end technology and expertise via a suite of core facilities known as Science Technology Platforms (STPs). The Crick STPs provide access to cutting-edge instrumentation and expertise across the range of applications necessary for modern biomedical research, including proteomics. About the Role
We are seeking a talented, experienced, and motivated Senior Laboratory Research Scientist in the Proteomics Scientific Technology Platform (STP) at the Francis Crick Institute. The post holder will help us provide a world-class platform to contribute towards key research in collaboration with the wider Crick scientific community. This is a lab-based position, responsible for driving forward qualitative and quantitative proteomic and clinical proteomic projects, from experimental design through sample preparation to data analysis. Key Responsibilities
Planning of experiments, decision-making about which pipeline to take, and independently executing experiments for projects. Performing both standard and bespoke proteomics experiments starting with sample preparation from a variety of biological sources using common biochemical methodologies for cell lysis, SDS-PAGE, in-gel, in-solution, TCA and acetone precipitation digest protocols, TMT labeling, high pH chromatographic fractionation and label-free quantification. LC-MS/MS nanoUHPLC data acquisition, evaluation, and processing of raw data. Requirements
The post holder should embody and demonstrate our core Crick values:
bold, open, collegial , in addition to the following: A PhD or equivalent experience gained through working in a mass spectrometry laboratory, including basic and advanced proteomic sample handling and processing protocols, and familiarity with instrument maintenance requirements. Detailed understanding of proteomics-related bioinformatics and associated software packages such as PEAKS, Mascot, Scaffold, MaxQuant, Spectronaut, DIA-NN, and Skyline. Experience with developing, optimizing, and applying next-generation proteomics and mass spectrometry methods such as DIA, DDA, label-free profiling, TMT, PRM, etc. Salary and Benefits
The salary for this role is estimated to be around £60,000 - £80,000 per annum, depending on experience. In addition to a competitive salary, we offer a comprehensive benefits package, including pension scheme, annual leave, and training opportunities. How to Apply
If you are interested in applying for this role, please submit your application via our website. All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
