This is a 12 month fixed term contract position. Based at Alderley Park, Medicines Discovery Catapult is a national Life Sciences service dedicated to turning drug discovery into commercial breakthroughs. We accelerate the development of science, and where there are areas of unmet patient need, we stimulate innovation. By transforming drug discovery, we can improve patient lives, increase the impact of the UK Life Sciences sector, and create a healthier society and economy. Our interventions work. Since we started, we have helped over 300 companies raise over £1bn of R&D investment. We seek passionate individuals who are eager to collaborate, innovate, and make a tangible difference in the field of drug discovery. Together, we can unlock new therapies, enhance patient outcomes, and ensure that the UK remains at the forefront of life sciences innovation. If you are ready to make an impact, we invite you to be part of our journey. The values of the Catapult are: Excellence – we continually strive to deliver the best solutions for our partners and for each other. In everything we do, we instil confidence. Integrity – Our strong commitment to what we do and why we are here drives us to do the right thing for our partners and each other. Community – We’re a strong team, we work well together, and we respect each other. Innovation - We’re driven by the need to make a difference. We constantly look for ways to drive change in our sector and how we work. The role of Senior Scientist – Translational Imaging Complex Medicines would suit a highly motivated self-starter who is passionate about the application of imaging techniques to study drug PK, biodistribution and cellular response. The successful candidate will apply their skills to support an important multi-partner collaboration to create a UK centre of excellence in nanomedicines. The candidate will bring expertise in working with in vivo mouse models and ex vivo tissues, to generate imaging data for drug discovery projects. They will be responsible for designing and running pre-clinical studies to monitor, assess and characterise the biodistribution of novel lipid nanoparticles (LNPs). The individual will work closely with colleagues in interdisciplinary project teams as well as our external collaborators. The opportunity to join a world-class laboratory team and contribute your ideas, insights, and creative science by working collaboratively with leaders in the field across the UK, should provide a fantastic platform for career development. Main duties and responsibilities Deliver high-quality protocols and data focused on analysis of tissue and cellular distribution and PK assessment of novel lipid nanoparticles, to support a multi-partner collaborative project. Independently design and implement strategies and programs of work to address project needs, including study set-up, execution of experiments including downstream analysis, data interpretation and reporting of results. Develop new approaches and workflows to address project questions and build new lab capability. Carry out labelling/radiolabelling of LNPs (optional). Deliver high-quality data in a complex and time-pressured research environment. Manage complex collaborative projects with external partners to completion. Contribute scientific insight and innovative technical approaches to enable more successful drug discovery programmes. Implement effective lab processes, experimental record keeping and safety. Maintain full awareness and adherence to Home Office project license and in vivo compliance. Apply effective communication and research collaboration skills, working with a wide range of colleagues in a range of academic and commercial organisations. Essential qualifications, experience and knowledge The successful candidates will have demonstrated experience in in vivo and ex vivo techniques, with either a PhD or substantial, relevant laboratory experience. Personal Home Office licence (PIL ABC). Extensive expertise in in vivo imaging, with a focus on PET imaging and data analysis; and in the deployment of advanced technologies to address bespoke project questions. Proven track record of delivering high-quality data and impact in a project environment. Practical experience of conventional in vivo techniques, including dosing via common routes, tumour/tissues collection, blood sampling & reporting clinical signs. Experienced in ex vivo techniques, including tissue processing, staining (IF/IHC), microscopy and data analysis. Experience of working in collaborative project teams, with both internal and external colleagues; experience of working with academic groups and SMEs is an advantage. Ability to communicate effectively with both experts and non-experts in the field. Desirable qualifications, experience and knowledge Pharmaceutical industry or other medicines discovery experience Experience with lipid nanoparticles (formulation, dosing, tissue distribution) Experience with PMOD software Experience in labelling/radiolabelling techniques, including QC analysis and stability techniques of labelled products Closing date:
Friday 17th January 2025 Please note the closing date for applications may be brought forward if a high volume of applications are received.
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